Journal article
Socioeconomic disadvantage and polygenic risk of overweight in early and mid-life: a longitudinal population cohort study spanning 12 years
JA Kerr, D Dumuid, M Downes, K Lange, M O'Connor, T Stanford, L Thornton, S Mavoa, K Lycett, TS Olds, B Edwards, J O'Sullivan, M Juonala, HND Le, R Saffery, D Burgner, M Wake
Lancet Regional Health Western Pacific | ELSEVIER | Published : 2024
Abstract
Background: We describe BMI by socioeconomic disadvantage and by polygenic risk in parallel cohorts of children and adults (their parents). We examine whether hypothetically intervening to reduce childhood disadvantage could reduce adolescent obesity. Methods: From a population-based cohort (N = 5107) with a mixed design (survey and direct assessment), 24–31% had genotype data: 1607 children (50% male) followed biennially from age 2–3 to 14–15; 2406 adults (36% male) followed from mean age 35–47 years. Exposures were polygenic risk score for BMI, and neighbourhood- and family-level socioeconomic disadvantage categorised as ‘most’ (top two cohort-specific quintiles), ‘average’, or ‘least’ dis..
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Awarded by Australian Institute of Family Studies
Funding Acknowledgements
This work was supported by the Australian National Health and Medical Research Council (NHMRC) Project Grants [1041352, 1109355] , The Royal Children's Hospital Foundation [2014-241] , Murdoch Children's Research Institute, The University of Melbourne, National Heart Foundation (NHF) of Australia [100660] and Financial Markets Foundation for Children [2014-055, 2016-310] , New Zealand Ministry of Business, Innovation and Employment (PROP-53087-INTCS-UOA) , and the National Centre for Longitudinal Studies. JA Kerr, M Downes, and M O'Connor were supported by the Melbourne Children's LifeCourse Platform, funded by Royal Children's Hospital Foundation grant (2018-984) . JA Kerr and D Dumuid are supported by the Centre of Research Excellence in Driving Global Investment in Adolescent Health funded by NHMRC (1171981) . D Dumuid is sup-ported by an ARC Discovery Early Career Award (DE230101174) . H Le is supported by Deakin post-doctoral research fellow funding. S Mavoa was supported by a NHMRC Early Career Fellowship (1121035) and a University of Melbourne Faculty of Medicine, Dentistry and Health Sciences Research Fellowship. K Lycett is supported by NHMRC Early Career Fellowship 1091124 and Honorary NHF Postdoctoral Fellowship (101239) . D Burgner is supported by an NHMRC Investigator Grant (1175744) . M Wake is supported by an NHMRC Principal Research Fellowship (1160906) . Research at the Murdoch Children's Research Institute is supported by the Victorian Government's Operational Infrastructure Program.